Background: Muscle mass was known to related with bone mineral density. However there were few data for affecting factor to this relationship. In this study, we investigated the affecting factor to the relationship between bone and muscle.
Subjects and Methods: The data from a population-based survey, namely, The Korea National Health and Nutrition Examination Survey (KNHANES) IV (08-09) & V(10) (18,007 subjects), were analyzed. We studied the relating factor (anthropometric data and insulin resistance) to bone mineral density (BMD)/[appendicular lean mass(ALM)/(height)2].
Result: With increasing age, BMD/ALM(ht)2 was increasing in men (B = 0.126, p < 0.001) but deceasing in women (B = ?0.408, p < 0.001). After adjusting age, fat mass (men: B = ?0.186, p < 0.001, women: B = ?0.162, p < 0.001) and waist circumference (men: B = ?0.186, p < 0.001, women: B = ?0.162, p < 0.001), fasting insulin level (men: B = ?0.108, p = 0.002, women: B = ?0.088, p = 0.016) was negatively related with BMD/ALM(ht)2. And insulin resistance (HOMA-IR) was also negatively related with BMD/ALM(ht)2 (men: B = ?0.115, p < 0.001, women: B = ?0.121, p < 0.001). HDL cholesterol level had positive relation with BMD/ALM(ht)2 (men: B = 0.081, p < 0.001, women: B = 0.115, p < 0.001).
Conclusion: In this study, bone and muscle relation was differing between men and women. And obesity and insulin resistance may be weakening the relationship between bone and muscle.
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